Tocris Bioscience

Biological Activity for Pregabalin

Anticonvulsant and antiepileptic; also used to treat neuropathic pain. Binds with high affinity and selectivity to the α2δ subunit of voltage-sensitive Ca2+ channels and modulates their activity. Displays anxiolytic-like activity in ethological and conflict models of anxiety. Analog of GABA (Cat. No. 0344).

Licensing Information

Sold for research purposes under agreement from Pfizer Inc.

Technical Data for Pregabalin

M. Wt 159.23 Formula C8H17NO2 Storage Store at RT CAS Number 148553-50-8 PubChem ID 5486971 InChI Key AYXYPKUFHZROOJ-ZETCQYMHSA-N Smiles CC(C)C[C@H](CN)CC(O)=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

References for Pregabalin

References are publications that support the biological activity of the product.

Field et al (2001) Pregabalin may represent a novel class of anxiolytic agents with a broad spectrum of activity. Br.J.Pharmacol. 132 1 PMID: 11156553

Kumar et al (2010) Evidence that prega. reduces neuropathic pain by inhibiting the spinal release of glutamate. J.Neurochem. 113 552 PMID: 20132471

Arain (2009) Pregabalin in the management of partial epilepsy. Neuropsych.Dis.Treat. 5 407

Keywords: Pregabalin, Pregabalin supplier, anticonvulsants, neuropathic, pain, GABA, analgesics, anxiolytics, a2d, alpha2delta, α2δ, voltage-sensitive, calcium, channels, Ca2+, Non-selective, Cav, Channels, 3775, Tocris Bioscience