Custom Synthesis Services

18 Aug.,2023

 

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Custom Synthesis

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BOC Sciences provides contract research, development and manufacturing services to help customers industrialize their products from research to clinical trials to commercialization. We offer lab scale custom synthesis, biosynthesis, bioconjugation and analytical services.

Custom Synthesis Small Molecule

We expertise in synthesis of a broad array of customized molecules. Besides, we specialize in chiral synthesis (asymmetric catalysis, chiral auxiliaries, biocatalysis, enantioselective organocatalysis, chiral pool synthesis and chiral resolution). We offer product upgrade service to improve product quality (recrystallization, prep HPLC, chiral HPLC, chiral resolution). Available documents for custom synthesis projects (additional fee might apply): synthesis report with procedure, high-performance liquid chromatography (HPLC), gas chromatography (GC), mass spectrometry (MS), nuclear magnetic resonance analyses (NMR), etc.

Nucleosides are important biological molecules that function as signaling molecules and as precursors to nucleotides needed for DNA and RNA synthesis. Drugs-based nucleotides are an emerging field in recent years. Nucleotide drugs are a variety of oligonucleotides (RNA) or oligodeoxyribonucleotides (DNA) with different functions, which have specific targets and mechanisms of action, so nucleotide drugs have a wide range of application prospects.

Heterocyclic compounds Synthesis

Heterocyclic compounds are organic compounds that contain a heterocyclic structure in the molecule. The atoms that make up the ring contain at least one heteroatom in addition to the carbon atom. The most common heteroatoms are nitrogen, sulfur and oxygen atoms. Heterocyclic compounds can be divided into two categories, alicyclic and aromatic heterocyclic. Heterocyclic compounds are commonly found in the structure of drug molecules.

Asymmetric synthesis, also known as chiral synthesis or enantioselective synthesis, is the branch of organic synthesis in which one or more chiral elements are introduced to the reactants via a chemical reaction. Asymmetric synthesis has a very important place in both drug synthesis and total synthesis of natural products, and has great importance in the screening of APIs and development of bio/pharmaceutical products.

BOC Sciences provides a wide range of services such as custom stable isotope labeling to support your regulatory, development or research programs.

Peptides are the bioactive substance related to various cellular functions in living organisms, consisting of multiple amino acids bound by peptide bonds in a certain order of arrangement. Peptides are often used in functional analysis, antibody research, and especially in drug development.

Bioconjugation represents the technique of giving a target substance with certain desired properties through the site-specific reaction between the biomolecules and exogenous moieties (usually one or several other molecules). Through such a covalent linkage approach, a broad range of innovative drug substances or end products is designed to improve the accuracy of disease diagnosis, pharmacokinetic properties, treatment efficacy and many other aspects.

Other Synthesis Services

  • Carbohydrate Synthesis
  • Steroids Synthesis
  • Amino acids and PNA monomers
  • Oligopeptide synthesis
  • Semi-synthesis and Total Synthesis of Natural Products
  • Building blocks, starting materials, and intermediates
  • Drug-like screening compounds
  • Derivatives of lead compounds
  • Functionalization of known bioactive compounds with covalent warheads and other moieties
  • Target substrates, inhibitors and activators
  • Reference compounds and potential impurities or contaminants
  • Combinatorial chemistry templates
  • Drug metabolites
  • And more...

Reaction Types

  • Acylation
  • Friedel-Crafts reaction
  • Stille coupling
  • Suzuki coupling
  • Asymmetric hydrogenation
  • Chiral resolution
  • Heterocyclic formation
  • High-pressure hydrogenation
  • Fluorination
  • Grignard reaction

An effective process R&D is an essential part of your drug development while it plays important role in controlling costs, ensuring product’s quality and meeting the requirements of regulations. More importantly, package solutions are available to address any problems and potential risks that significantly impact the quality of your products.

We provide a seamless one stop process development service, effectively speeding up the process of new drug development and reducing overall costs.
We can provide GMP production for HPAPI, API and Peptides.

BOC Sciences' multidisciplinary team can provide you with cGMP API and biologic production using market-leading expertise, state-of-the-art facilities and state-of-the-art equipment.

Our Advantages

  • Synthetic Route Design and Optimization
  • Process Research, Development, and Optimization
  • Optimization and search of the best cost- and time- efficient synthetic route
  • Small- and Large-Scale Chemistry Capabilities
  • Advanced Synthetic and Analytical Platform
  • Expert Project Management
  • Cost-Effectiveness and High Efficiency
  • Creativity and problem solving in the field of chemistry and biology
  • Reliability and strict confidentiality

Project Workflow

Case Study - Route Design

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