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Do you need 2-CHLORO-5-CHLOROMETHYLPYRIDINE solution? Choose us as your partner and we will provide you with a solution that will satisfy you.
The company has a group of cooperation teams engaged in the Methyl Pyridine Intermediate industry for many years, with dedication, innovation spirit and service awareness, and has established a sound quality control and management system to ensure product quality.
Here is a look at a reaction directly from our proven organic chemistry flash card system:
Esterification of Acid Chloride
Overall Big Picture: In this reaction, an acid halide is reacted with an alcohol to give an ester.
Acid Chloride + Alcohol → Ester
Key Tip: A mild base is required to drive the reaction forward.
Key Comparison: This reaction is only possible due to the high reactivity of acid halides for nucleophiles, even weak ones like alcohols.
Mechanism Hint: Collapse of the addition intermediate is propagated by deprotonating by pyridine, which helps to drive the reaction forward.
Note: When this reaction is carried out using p-toluensufonyl chloride (tosyl group), this reaction is a good protecting group for alcohols.
First window: acetyl chloride
Middle window: alcohol, pyridine
Last window: methyl ester
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