5 Must-Have Features in a Fluoride Manufacturers

01 Sep.,2025

 

5 Topical Fluoride Therapy Companies Worldwide

The global Topical Fluoride Therapy Market expansion is accelerating the market's growth during the anticipated timeframe. Due to the existence of businesses selling sodium fluoride to both local and international markets, there is more potential for revenue generation, which will allow the market to grow throughout the projection period. The pandemic's global effects on the chemical sector were anticipated to have an impact on the sodium fluoride market in . However, as the economy improves, businesses are picking up steam and are expected to experience steady market expansion from the middle of through the end of . The market is divided into online and offline modes based on the distribution channels used. Offline now has the most market share.

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Dentsply Sirona, VOCO, Colgate, 3M, Ultradent Products, Young Dental, Philips, DRRDENTAL, DMG Dental, Ivoclar Vivadent, Water Pik, GC Corporation, MPL, Medicom, Centrix, etc. are some of the key companies profiled in the topical fluoride therapy market.

Business Research Insights Presents Top 5 Players in the Topical Fluoride Therapy Industry Worldwide

1. Quality Chemicals

A European manufacturer specializing in the production of ultra-pure salts is called Quality Chemicals. The business offers raw materials to a variety of end-use industries. It is a chemical science corporation. Pharmaceuticals, biopharmaceuticals, veterinary medicine, oral care, and many more products are among them. Among the sodium fluoride product varieties offered by the company are sodium fluoride GMP PH, sodium fluoride GMP QP, sodium fluoride PA, sodium fluoride PE, sodium fluoride PRS, sodium fluoride QP, and sodium fluoride RA.

2. Crystran Ltd.

Located in the UK, Crystran Ltd. is a modestly sized manufacturing business. It deals with making IR and UV components out of materials like crystal or cutting-edge glasses that are used for transmission qualities. As one of the optical materials with the lowest refractive index, the company offers sodium fluoride, which is a substance of interest as a Cerenkov radiator in particle physics research.

3. Prayon

Using sustainable technology, Prayon, a multinational chemical firm with headquarters in Engis, Walloon Region, Belgium, offers high-quality goods and services to meet consumer demands. The business creates a variety of inorganic fluorides, such as potassium fluosilicate, sodium fluosilicate, and sodium fluoride. The business also claims of having a total capacity of more than 30,000 tons and being the innovator of these items in the European region. The company's sodium fluoride is used, among other things, to treat vitreous glazes, add fluoride to dental products, and treat water.

4. Colgate-Palmolive

Colgate-Palmolive Company is a multinational American corporation that produces and sells pet meals, dental and other personal care products, household and commercial cleaning goods, and more than 200 other nations and territories across the world. The corporate office is in New York City. The Colgate-Palmolive corporation sells toothpaste called PreviDent Sensitive (Rx only). To stop cavities, this contains 5% potassium nitrate and 1.1% sodium fluoride. Features of the product include a liquid gel consistency with a faint mint flavor. Benefits of the product include therapeutic decay prevention for exposed root surfaces, faster fluoride dispersion compared to paste-form Rx toothpaste, and lower levels of abrasion.

5. 3M

Products containing sodium fluoride are also available from 3M. These include 3M Vanish, a white varnish with tri-calcium phosphate, and 5% sodium fluoride. The product is an improved clear varnish with a 24-hour prolonged release of calcium, phosphate, and fluoride. The formulation of the product is intended to keep in contact with teeth for a longer period of time. By offering this sophisticated and powerful defense, strong acid-resistant minerals are also added to the surface of teeth. A different product is an anti-cavity toothpaste with sodium fluoride found in 3MTM Clinpro . The product aids in tooth enamel strengthening, caries prevention, and the reversal of lesions with white spots. The product comes in the flavors of bubble gum, mint, vanilla, and spearmint.

COVID-19 Accelerated R&D Around Potential Benefits of Topical Fluoride Therapy

Due to the rising frequency of dental-related illnesses, fluoride treatments are receiving a lot of attention globally. Fluoride also prevents dental caries by altering the metabolism of bacteria that cause caries. Due to the rising frequency of dental-related illnesses, fluoride treatments are receiving a lot of attention globally. Fluoride has played a significant role in the decrease of dental caries prevalence and severity in the US and other economically developed countries. The global topical fluoride therapy market was significantly impacted by the COVID-19 pandemic.

Since governments were primarily focused on the primary healthcare sectors, the dentistry industry also suffered. The market for topical fluoride therapy was significantly impacted by this. Additionally, the market encountered inefficiencies including labor shortages and disruptions in the supply. The market, though, is reportedly making a gradual comeback. It is projected that demand would increase in the market as the majority of nations loosen their COVID-19 protocols. As a result, there is a growing need for intelligent, reasonably priced, and customized healthcare services. The COVID-19 epidemic has also increased demand for healthcare and related goods and services, boosting the performance of the healthcare sector as a whole. Moreover, it is projected that the market will expand due to the rising prevalence of tooth decay and the general decline in oral health.

Fluoride varnishes: What's the difference, and which one is best?

Editor's note: Originally posted in and updated regularly

Fluoride’s effectiveness in preventing tooth decay and dentinal hypersensitivity is well known. Fluoride treatments are supported by the World Health Organization, the Centers for Disease Control and Prevention (CDC), as well as many other agencies. Fluoridation of public water is considered to be one of the most successful public health acts in the fight against dental decay, according to the CDC.1 There are numerous types of professional fluoride applications that can be provided in the dental office as treatment for adults and children. The American Dental Association recognizes 5% sodium fluoride (NaF) or 2.26% fluoride content varnish treatment for the benefit of caries prevention when given at least twice per year to children up to age 18.2 Sodium fluoride varnishes are also recommended for prevention of root caries in adults when administered at least twice a year at patients’ prophylaxis appointments. It is easily interpreted that fluoride varnishes are beneficial to all age groups, especially children and individuals with high caries risk.3 So, what is the best type of varnish, and what are the differences between the various topical fluoride treatments?

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Currently, we have no studies to support the clinical benefits of one type of professional fluoride treatment over another. It has been shown that the frequency and duration of tooth-to-fluoride contact are the greatest contributors to the success of a treatment modality. When comparing fluoride carriers such as varnish to toothpaste and rinse, there are no proven benefits of a specific delivery system.4 So, why a varnish, and what should we look for in one?5

Why varnishes?

As a delivery system, varnish is preferred for its ease of use, prolonged fluoride exposure time, and relative safety. A concern with other carrier modalities is that there is an increased risk of ingestion, as well as decreased contact time with the teeth. Most varnishes on the market contain 5% NaF with an alcohol- and resin-based solution. The evaporation of the alcohol makes the system fast drying, and the resin functions to allow the fluoride to adhere to the teeth. The most common resin additive is colophony, a rosin derived from pine tree sap. The carrier is the cause of the main complaint about varnish, in that it is “sticky” and leaves a noticeable film on the teeth.2

You might also be interested in: 3 ways hygienists can boost acceptance of fluoride varnish

A comparison of products

Not all products are created equal, as science has developed different additives to place in varnishes in an attempt to increase their effectiveness. Following is a comparison of some of the most common varnishes on the market.

Duraphat (Colgate) was the first varnish on the market in . This varnish contains 5% NaF suspended in an alcohol-based solution of natural resins. Duraphat varnish is tinted; this is reported to be for easy visualization. The product has a high viscosity.

MI Varnish (GC America) is unlike any other varnish. It contains 5% NaF + Recaldent (CPP-ACP). Recaldent is a novel combination of casein phosphopeptide (CPP) and amorphous calcium phosphate (ACP). The casein peptide naturally occurs in milk and binds to teeth in the oral cavity, mucosa, and even biofilm, which allows the ACP to be stabilized until it reaches the teeth to recalcify tooth structures.7 MI paste and Recaldent have been greatly studied and proven to be an effective way to remineralize teeth.

Fluor Protector S (Ivoclar Vivadent) is different in that it contains 1.5% ammonium fluoride (NH4F). This varnish uses ethanol and water as solvents to allow for a decreased viscosity and increased wetting and flowability. After the solvent evaporates, the fluoride concentration is up to four times higher on the tooth surface, providing 3% fluoride content locally. To increase efficacy, a polymer additive helps the varnish to adhere to the teeth. Its transparency, homogeneity, and thin viscosity provide a high level of patient acceptance and satisfaction.8

Kolorz ClearShield (DMG America) contains 5% NaF. This varnish, as named, goes on completely clear for an esthetic appearance. This product works to improve the varnish experience with its many different flavor choices, such as watermelon, bubblegum, mint, cookie dough, and caramel, making each varnish treatment more enjoyable.

Vanish Varnish (3M) is a unique product in that it is proven to release fluoride over the course of 24 hours. As we have read, one of the greatest indicators of a fluoride treatment’s effectiveness is its duration. The longer the duration of contact with the fluoride, the greater effect it can have on teeth. Another unique component of this product is that it has tricalcium phosphate, in addition to the NaF, to help with the remineralization of teeth. This varnish is an alcohol-based suspension of modified rosin. The product reports an increased flowability and a decreased film thickness.9 Another major advantage of this varnish is its effectiveness on polished and unpolished teeth, as well as in wet or dry environments. The product’s extended release is a great advantage too.  

References

1. Water fluoridation basics. Division of Oral Health. National Center for Chronic Disease Prevention and Health Promotion. Centers for Disease Control and Prevention website. https://www.cdc.gov/fluoridation/basics/index.htm. Updated January 24, . Accessed February 17, .

2. Professionally applied topical fluoride: Evidence-based clinical recommendations. J Am Dent Assoc. ;137(8):-. doi:10./jada.archive..

3. Weyant RJ, Tracy SL, Anselmo TT, et al. Topical fluoride for caries prevention: Executive summary of the updated clinical recommendations and supporting systematic review. J Am Dent Assoc. ;144(11):-. doi:10./jada.archive..

4. Marinho VCC, Higgins JPT, Sheiham A, Logan S. One topical fluoride (toothpastes, or mouthrinses, or gels, or varnishes) versus another for preventing dental caries in children and adolescents. Cochrane Database Syst Rev. (1):CD. doi:10./.CD.pub2

5. Karlinsey KL. Fluoride varnishes: Why they work & what to look for. EC Dent Sci. ;5(6):-. 

6. Martel S. A new generation of fluoride varnish is coming to you. Oral Health Group website. https://www.oralhealthgroup.com/features/new-generation-fluoride-varnish-coming/. Published September 14, .

7. GC America proudly introduces MI Paste & MI Paste Plus. Frequently asked questions. GC America MI Paste Family website. http://www.mi-paste.com/FAQ_MIP.php.

8. Fluor Protector S. Ivoclar Vivadent website. https://www.ivoclarvivadent.com/en/p/all/fluor-protector-s.

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