In flow chemistry, also called reactor engineering, a chemical reaction is run in a continuously flowing stream rather than in batch production. In other words, pumps move fluid into a reactor, and where tubes join one another, the fluids contact one another. If these fluids are reactive, a reaction takes place. Flow chemistry is a well-established technique for use at a large scale when manufacturing large quantities of a given material. However, the term has only been coined recently for its application on a laboratory scale by chemists and describes small pilot plants, and lab-scale continuous plants.[1] Often, microreactors are used.[2]
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Choosing to run a chemical reaction using flow chemistry, either in a microreactor or other mixing device offers a variety of pros and cons.
Typical drivers are higher yields/selectivities, less needed manpower, or a higher safety level.
The drawbacks have been discussed in view of establishing small scale continuous production processes by Pashkova and Greiner.[7]
Continuous reactors are typically tube-like and manufactured from non-reactive materials such as stainless steel, glass, and polymers. Mixing methods include diffusion alone (if the diameter of the reactor is small e.g. <1 mm, such as in microreactors) and static mixers. Continuous flow reactors allow good control over reaction conditions including heat transfer, time, and mixing.
The residence time of the reagents in the reactor (i.e. the amount of time that the reaction is heated or cooled) is calculated from the volume of the reactor and the flow rate through it:
Therefore, to achieve a longer residence time, reagents can be pumped more slowly and/or a larger volume reactor used. Production rates can vary from nanoliters to liters per minute.
Some examples of flow reactors are spinning disk reactors;[8] spinning tube reactors; multi-cell flow reactors; oscillatory flow reactors; microreactors; hex reactors; and 'aspirator reactors'. In an aspirator reactor a pump propels one reagent, which causes a reactant to be sucked in. This type of reactor was patented around by the Nobel company for the production of nitroglycerin.
The smaller scale of microflow reactors or microreactors can make them ideal for process development experiments. Although it is possible to operate flow processes at a ton scale, synthetic efficiency benefits from improved thermal and mass transfer as well as mass transport.
Laboratory scale flow reactors are ideal systems for using gases, particularly those that are toxic or associated with other hazards. The gas reactions that have been most successfully adapted to flow are hydrogenation and carbonylation,[9][10] although work has also been performed using other gases, e.g. ethylene and ozone.[11]
Reasons for the suitability of flow systems for hazardous gas handling are:
Continuous flow photochemistry offers multiple advantages over batch photochemistry. Photochemical reactions are driven by the number of photons that are able to activate molecules causing the desired reaction. The large surface area to volume ratio of a microreactor maximizes the illumination, and at the same time allows for efficient cooling, which decreases the thermal side products.
Continuous flow electrochemistry like continuous photochemistry offers many advantages over analogous batch conditions. Electrochemistry like Photochemical reactions can be considered as 'reagent-less' reactions. In an electrochemical reaction the reaction is facilitated by the number of electrons that are able to activate molecules causing the desired reaction. Continuous electrochemistry apparatus reduces the distance between the electrodes used to allow better control of the number of electrons transferred to the reaction media enabling better control and selectivity.[12] Recent developments in electrochemical flow-systems enabled the combination of reaction-oriented electrochemical flow systems with species-focused spectroscopy which allows a complete analysis of reactions involving multiple electron transfer steps, as well as unstable intermediates.[13] These systems which are referred to as spectroelectrochemistry systems can enable the use of UV-vis as well as more complex methods such as electrochemiluminescence. Furthermore, using electrochemistry allows another degree of flexibility since the user has control not only on the flow parameters and the nature of the electrochemical measurement itself but also on the geometry or nature of the electrode (or electrodes in the case of an electrode array).[14]
The process development change from a serial approach to a parallel approach. In batch the chemist works first followed by the chemical engineer. In flow chemistry this changes to a parallel approach, where chemist and chemical engineer work interactively. Typically there is a plant setup in the lab, which is a tool for both. This setup can be either commercial or noncommercial. The development scale can be small (ml/hour) for idea verification using a chip system and in the range of a couple of liters per hour for scalable systems like the flow miniplant technology. Chip systems are mainly used for a liquid-liquid application while flow miniplant systems can deal with solids or viscous material.
Microwave reactors are frequently used for small-scale batch chemistry. However, due to the extremes of temperature and pressure reached in a microwave it is often difficult to transfer these reactions to conventional non-microwave apparatus for subsequent development, leading to difficulties with scaling studies. A flow reactor with suitable high-temperature ability and pressure control can directly and accurately mimic the conditions created in a microwave reactor.[15] This eases the synthesis of larger quantities by extending reaction time.
Flow systems can be scaled to the tons per hour scale. Plant redesign (batch to conti[clarification needed] for an existing plant), Unit Operation (exchanging only one reaction step) and Modular Multi-purpose (Cutting a continuous plant into modular units) are typical realization solutions for flow processes.
It is possible to run experiments in flow using more sophisticated techniques, such as solid phase chemistries. Solid phase reagents, catalysts or scavengers can be used in solution and pumped through glass columns, for example, the synthesis of alkaloid natural product oxomaritidine using solid phase chemistries.[16]
There is an increasing interest in polymerization as a continuous flow process. For example, Reversible Addition-Fragmentation chain Transfer or RAFT polymerization.[17][18][19]
Continuous flow techniques have also been used for the controlled generation of nanoparticles.[20] The very rapid mixing and excellent temperature control of microreactors are able to give consistent and narrow particle size distribution of nanoparticles.
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As discussed above, running experiments in continuous flow systems is difficult, especially when one is developing new chemical reactions, which requires screening of multiple components, varying stoichiometry, temperature, and residence time. In continuous flow, experiments are performed serially, which means one experimental condition can be tested. Experimental throughput is highly variable and as typically five times the residence time is needed for obtaining steady state. For temperature variation the thermal mass of the reactor as well as peripherals such as fluid baths needs to be considered. More often than not, the analysis time needs to be considered.
Segmented flow is an approach that improves upon the speed in which screening, optimization, and libraries can be conducted in flow chemistry. Segmented flow uses a "Plug Flow" approach where specific volumetric experimental mixtures are created and then injected into a high-pressure flow reactor. Diffusion of the segment (reaction mixture) is minimized by using immiscible solvent on the leading and rear ends of the segment.
One of the primary benefits of segmented flow chemistry is the ability to run experiments in a serial/parallel manner where experiments that share the same residence time and temperature can be repeatedly created and injected. In addition, the volume of each experiment is independent of that of the volume of the flow tube thereby saving a significant amount of reactant per experiment. When performing reaction screening and libraries, segment composition is typically varied by the composition of matter. When performing reaction optimization, segments vary by stoichiometry.
Segmented flow is also used with online LCMS, both analytical and preparative where the segments are detected when exiting the reactor using UV and subsequently diluted for analytical LCMS or injected directly for preparative LCMS.
Flow chemistry is also known as continuous flow or plug flow chemistry. It involves a chemical reaction run in a continuous flow stream. The process offers the potential for the efficient manufacture of chemical products. Significant breakthroughs using flow chemistry systems are in the production of Tamoxifen (Breast Cancer) and Artemisinin (Malaria).
Reactants are first pumped into a mixing device. Flow continues through a temperature controlled reactor until the reaction is complete. The reactor can be a simple pipe/tube or a complex micro-structured device. The mixing device and reactor are maintained at the precise temperature to promote the desired reaction. The reactants may also be exposed to an electrical flux or a photon flux to promote an electrochemical or photochemical reaction.
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In Flow, chemistry reagents are pumped under pressure and flow continuously through the reactor. This contrasts with batch reactors where all reagents are loaded into a vessel at the start
Reaction time is determined by the time the reagents take to flow through the reactor. This period is called the residence time.
Reaction stoichiometry is controlled by the relative flow rates of the reactants. The concentration of one reagent relative to another can be increased simply by pumping that reagent at a higher flow rate.
Flow reactors have excellent heat transfer when compared with batch reactors. This is because the surface area to volume ratio of flow reactors is much greater than that of batch reactors.
Reactors designed for flow chemistry have high rates of mass transfer. This is due to the small sizes and good mixing that is possible.
Flow reactions can simply be run for longer. This produces more material.
Flow offers the chemist precise control of the four critical reaction parameters. These parameters are stoichiometry, mixing, temperature, and reaction time
When reactions are run in continuous flow only small quantities of potentially hazardous materials are “in-process”.
Reactive intermediates don’t need to be isolated. Flow reactions can be easily run in sequence or “telescoped”.
Flow reactors do not require a head space. The pressure within the reactor is controlled by a back pressure regulator (BPR). With high pressure batch reactors, the gas within the headspace must be pressurised.
Flow reactors can be arranged to have very little or even no back-mixing