The viscosity of HPMC shapes properties such as water-retaining ability, thickening effect, and retarding performance. Thus, it is a crucial indicator for evaluating and selecting HPMC.
Before discussing the viscosity of HPMC, it is important to note that even for the same solution, results can vary depending on testing methods. There are some common methods to measure HPMC viscosity including Brookfield, Hakke, and Hoppler. The instruments, solution concentrations, and testing environments involved in these methods are different. Therefore, when assessing the viscosity of an HPMC polymer, ensure that details such as rotor type, temperature, and solution concentration are taken into account.
Take LANDERCOLL K200, the TDS points that its viscosity of 65,000-80,000 mPas is obtained using Brookfield-RV under a 2% solution at 20℃.
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HPMC is susceptible to degradation by cellulase, an enzyme produced by fungi, bacteria, and protozoans that catalyze cellulolysis. When cellulase attacks HPMC, it primarily targets the unetherified glucose units in the HPMC structure. As a linear polymer, HPMC faces a sharp decline in viscosity once a glucose unit is damaged. However, such enzymes find it difficult to degrade the molecular chain if glucose units are etherified. Therefore, the higher the degree of etherification substitution (DS value) of HPMC, the more stable it is.
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The content of active ingredients in HPMC is directly proportional to its cost-effectiveness, which means better performance at the same dosage. The active ingredient in HPMC is etherified cellulose, an organic substance. Its content can be measured by the ash content from calcined HPMC. Generally, a higher ash value indicates a lower content of active ingredients. In the TDS of LANDERCOLL HPMC, you could see the ash content is no more than 5%, implying the high purity of our products.
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