How to Save Money When Buying how to make HPMC solution

16 Jun.,2025

 

The Hidden Cost of Cheap Empty Capsules - Blog CapsCanada

If you’ve received pricing from multiple manufacturers for two-piece hard capsules, you know that there can be significant price differences from one brand to the next. With margins being squeezed across the industry, it can be tempting to simply go with the lowest bid. After all, a capsule is a capsule, right?

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Wrong. All capsules are definitely not created equal. Quality matters. In fact, capsule quality makes such a difference during the filling process that those “inexpensive” capsules can quickly become very, very expensive. 

Low-cost capsules result in low yield


When you buy high-quality capsules, such as CapsCanada’s G-CAPS® gelatin capsules or K-CAPS® HPMC capsules, you get capsules that have excellent runnability on high-speed filling machines. Simply put, high-quality capsules minimize waste and maximize yield. 

When you buy low-quality capsules, often coming in from overseas in bulk, non-temperature- controlled containers, you are more likely to face problems during the production process that will negatively impact your yield, such as:


Imprecise capsule-to-tooling fit – Capsules that do not seat correctly in the tooling are prone to bad joining, creating critical defects such as splits and tucks.

Weak capsule shell construction –  To save material, some capsule manufacturers will use the bare minimum amount of material to make the capsules. When evaluating capsules, be aware that the weight of the empty capsules can be an indicator for capsule wall strength.  Thinner walls will result in more denting, pin-holes, and split and tuck defects. 

• Poor separation properties – Low-cost manufacturers may run their hard capsule manufacturing machines at rates which exceed the process capabilities for creating consistent product. They speed up the critical drying step of the process, which creates variation in the finished product. The final result is capsules that do not separate smoothly, thereby creating product waste, dirty machinery and extra down time, not to mention long and frustrating days for your encapsulation operators. 

Poor closing properties – There’s nothing like shipping out finished product that either comes open or leaks before reaching the consumer. If you have a one percent defect rate, every customer who opens a 100-count bottle will receive a defective capsule.  

How will low yield impact your profitability?

When analyzing the true cost of “inexpensive” capsules, you must consider all of the following factors. If you leave any of these factors out of the analysis you will not be looking at the true total cost of goods for your finished product:

• Cost of capsules, per thousand capsules.

• Total cost of blended fill material, per thousand capsules.

• Machine operator labor cost, including taxes and benefits.
 
• Cost of waste, including capsule and fill material costs, as well as the labor costs associated with troubleshooting, inspections, rework, machine down time, and the need to run the machinery at slower speeds.


• Cost of returns and reputational damage, if quality problems are not caught before the product is shipped.

Run the numbers. If one capsule results in 3% waste of capsules and fill material and the other only has 0.03% waste, how will that affect your profitability? What if the cheap capsules result in 5% waste? When looked at in this way, which capsule will result in a higher profit margin? 


In most scenarios the higher-quality capsule will actually save you money by reducing waste, downtime and problems.

Conclusion

Controlling each of the critical variables is what breeds success in encapsulation. This begins with high-quality empty capsules, and includes the filling machine condition, operator training and fill material. When you invest a little more for higher-quality capsules, you set your operations team up for success. Plus, when you work with a high-quality capsule supplier, their technical services team can help you optimize your entire capsule filling operation, from machine setup to operator training. 

Capsule Size Guide | Interactive Specification Chart

You might be asking yourself what is the best size capsule to choose when encapsulating powders. You are right to be asking yourself this question before starting a new formulation. It is crucial to think about this before starting to produce capsules and will save time and money in the long run when done correctly. 

There are standard size capsules that are named by numerical values. They are numbered: 000, 00, 0, 1, 2, 3, 4 and 5. These sizes are the same for all types of Gelatin, HPMC and Pullulan. The majority of capsule filling machinery are manufactured to be compatible with these standard sizes.

We have put together this guide to help you choose the best size for your needs.

Below is an interactive chart to help you choose the best fit. Click on each size to highlight the specifications of that size capsule.

Contact us to discuss your requirements of how to make HPMC solution. Our experienced sales team can help you identify the options that best suit your needs.


Factors to Consider

When choosing a suitable size of capsule for your purposes there is a balance between the:

Required dosage

Volume of your mix

Ease of swallowing

Type of capsule being used

Required dosage

The required dosage comes down to how much of the active ingredient or ingredients is necessary for the product to be effective. You will need to decide how much of a dose you would like to be in each capsule e.g. mg of Vitamin C

This will then be combined with excipients to help the product flow through the machine. Once mixed this is known as a “mix”.

You will need there to be the correct dose of ingredient within the mix in each capsule. If there is too much for one capsule you can either try to fit the powder in one capsules or you may want to consider spreading the dose over multiple capsules. E.g. rather than 1 #000 capsule splitting it over 3 #00.

Volume of the Mix

The volume of the mix will depend on the bulk density of the powders that make up your mix. We have a tool and guide on bulk density to help calculate the bulk density of your mix. 

You need to know the bulk density of your mix so that you can work out how much active ingredient ends up in each capsule. It may result in you having to alter your mix slightly or spread the dose over more than one capsule. 

Ease of Swallowing

Sometimes the sizes can be selected simply by the physical size of the capsule. For example when choosing a capsule for a child or an animal who might not be able to swallow larger capsules. 

The reason that size 00 and size 0 are the most commonly used capsules in manufacturing is that they have adequate volume for a lot of mixes as well as being easy for humans to swallow. 

Type of Capsule

Certain capsules such as Pullulan are only available in certain sizes. Determining the type of capsule you would like to produce may dictate your choice. 

We have created this table to show the different capsules available for Gelatin, HPMC and Pullulan.

For more information, please visit is hydroxyethylcellulose safe.

Capsule Type #000 #00 #0 #1 #2 #3 #4 #5 Gelatin HMPC Vegetable